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New survey shows cannabis helps 90% of arthritis patients
While medical cannabis remains a contentious subject in the UK as patients struggle to get access, the results of a new survey show just how much cannabis has been embraced by people…
Healthy lifestyle may protect against dementia: Not smoking, avoiding alcohol and exercising more ‘cuts the risk of the memory-robbing disorder by a THIRD’
The study by Dutch academics followed 6,000 people for an average of 14 yearsThey found having unhealthy habits raises the risk of dementia by around 29%But an unhealthy lifestyle 'made…
CBD helps 3 out of every 4 children with autism
Compelling evidence has come to light from research-based in Israel backing the therapeutic use of medical cannabis and cannabidiol (CBD) for young people with autism. Clinical studies in using CBD…
Researchers discover genetic variant that could ‘protect against Alzheimer’s by helping to get rid of toxic protein clumps in the brain’
Variations in the gene MS4A4A boosted levels of receptor TREM2 in spinal fluid TREM2 helps remove damaged nerve cells; low levels linked to Alzheimer'sReceptor 'ingests' the protein amyloid β, causes plaque…
Recreational marijuana legalization reduces opioid deaths by 20%: study
The legal status of marijuana has shifted significantly over the past two decades: 10 states and Washington, DC now allow its recreational use (Illinois will follow in January), while 34…
Scientists discover massive new organ under our SKIN that causes us to feel pain
Mesh-like organ within the skin consists of glial cells; have hair-like structuresThese structures are thought to be sensitive to external stimuli, like heatWhen glial cells were blocked in mice, their sensation…
Alfie Dingley, 7, had 75 seizures a day until he started taking cannabis oil. One year after the law was changed to help him, the jury is still out on whether it really works
Alfie Dingley, 7, suffered up to 75 seizures a day before taking cannabis oil dropsHe was hospitalised almost once a week before he began his cannabis treatmentThe government changed the…
Scientist discovers new antibacterial proteins in SNAIL SLIME while trying to prove to her biologist husband his own experiment on the molluscs was ‘all wrong’
Dr Sarah Pitt identified proteins in the slime which could fight bacteria It was effective against 'superbug' Pseudomonas aeruginosaThis causes lung infections in cystic fibrosis patients and many other infectionsThe discovery…
European panel okays GW Pharma cannabis drug for epilepsy
GW Pharmaceuticals' marijuana-based treatment Epidyolex has won a positive recommendation for marketing approval from a European Medicines Agency (EMA) panel on Friday for use as an additional treatment for two…
People who eat dark chocolate are less likely to be depressed ‘because its psychoactive ingredients produce a feeling of euphoria similar to cannabis’
Scientists quizzed more than 13,000 people about their chocolate consumptionThose who ate dark chocolate were less likely to have depressive symptomsBut no such link existed among volunteers who had milk…
CBD may make you less aggressive: Tests show the cannabis-derived compound activates two key brain receptors and calms mice down
Scientists tested various doses of CBD on aggressive miceCBD made the mice attack less often than those not given any at allMore experiments found receptors which play a part in the…
Cure for heart failure moves ‘one giant step closer’ as scientists successfully regenerate dead tissue in rats using stem cells
Combining heart cells with stem cells could make heart tissue grow backAround 900,000 people in the UK have heart failure, as well as 5.7m AmericansStem cell therapy has failed in…
The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A1 Receptors
Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid with anti-inflammatory activity mediated by enhancing adenosine signaling. As the adenosine A1 receptor activation confers protection against ischemia/reperfusion (I/R)-induced ventricular arrhythmias, we hypothesized that CBD…
Acute administration of cannabidiol in vivo suppresses ischaemia‐induced cardiac arrhythmias and reduces infarct size when given at reperfusion
Background and purpose: Cannabidiol (CBD) is a phytocannabinoid, with anti‐apoptotic, anti‐inflammatory and antioxidant effects and has recently been shown to exert a tissue sparing effect during chronic myocardial ischaemia and reperfusion…
Chapter Ten – Cannabinoids in the Cardiovascular System
Cannabinoids are known to modulate cardiovascular functions including heart rate, vascular tone, and blood pressure in humans and animal models. Essential components of the endocannabinoid system, namely, the production, degradation, and signaling…
Pharmacologic Effects of Cannabidiol on Acute Reperfused Myocardial Infarction in Rabbits: Evaluated With 3.0T Cardiac Magnetic Resonance Imaging and Histopathology
Cannabidiol (CBD) has anti-inflammatory effects. We explored its therapeutic effects on cardiac ischemia–reperfusion injury with an experimental imaging platform. Reperfused acute myocardial infarction (AMI) was induced in rabbits with a…
Is the cardiovascular system a therapeutic target for cannabidiol?
Cannabidiol (CBD) has beneficial effects in disorders as wide ranging as diabetes, Huntington's disease, cancer and colitis. Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system.…
Contribution of endocannabinoids in the endothelial protection afforded by ischemic preconditioning in the isolated rat heart
The aim of the present study was to assess the contribution of endogenous cannabinoids in the protective effect of ischemic preconditioning on the endothelial function in coronary arteries of the…
Analgesic, Respiratory and Heart Rate Effects of Cannabinoid and Opioid Agonists in Rhesus Monkeys: Antagonist Effects of SR 141716A ,
This study characterized the antinociceptive, respiratory and heart rate effects of the cannabinoid receptor agonists Δ-9-tetrahydrocannabinol (Δ-9-THC) and WIN 55212 {(R)-(+)-2,3-dihydro-5-methyl-3-[(4-morpholinyl)methyl]pyrol-[1,2,3-de]-1,4-benzoxazin-6-yl)(1-naphtalenyl)methanone monomethanesulfonate}, N-arachidonyl ethanolamide (anandamide) and the mu and kappa opioid receptor agonists heroin…
Endogenous cannabinoids contribute to remote ischemic preconditioning via cannabinoid CB2 receptors in the rat heart
In addition to well-known neurobehavioral effects, endogenous cannabinoids exert diverse cardiovascular actions. Recently, they have been suggested to protect the myocardium against ischemia/reperfusion injury. The aim of this study is…
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