Effects of cannabinoids in Amyotrophic Lateral Sclerosis (ALS) murine models: a systematic review and meta‐analysis

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder that results from motor neuron damage. Cannabinoids have been proposed as treatments for ALS because of their anti‐excitotoxicity, anti‐oxidant and anti‐inflammatory effects.…

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The CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive motor neuron loss, paralysis and death within 2–5 years of diagnosis. Currently, no effective pharmacological agents exist for the treatment…

Continue ReadingThe CB2 cannabinoid agonist AM‐1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset

AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis

Effective treatment for amyotrophic lateral sclerosis (ALS) remains elusive. Motor neuron degeneration is the primary pathology in ALS; however non-neuronal cells contribute to the disease process. In particular, inflammatory processes have been…

Continue ReadingAM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid

Effective treatment for amyotrophic lateral sclerosis (ALS) remains elusive. Two of the primary hypotheses underlying motor neuron vulnerability are susceptibility to excitotoxicity and oxidative damage. There is rapidly emerging evidence…

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Cannabidiol and Other Cannabinoids Reduce Microglial Activation In Vitro and In Vivo: Relevance to Alzheimer’s Disease

Microglial activation is an invariant feature of Alzheimer's disease (AD). It is noteworthy that cannabinoids are neuroprotective by preventing β-amyloid (Aβ)-induced microglial activation both in vitro and in vivo. On…

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Cannabinoid CB2 receptor: a new target for controlling neural cell survival?

Two types of cannabinoid receptor have been cloned and characterized. Whereas CB1 receptors are ubiquitously expressed in neurons of the CNS, CB2 receptors have been thought to be absent from the CNS.…

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Alzheimer’s disease; taking the edge off with cannabinoids?

Alzheimer's disease is an age‐related neurodegenerative condition associated with cognitive decline. The pathological hallmarks of the disease are the deposition of β‐amyloid protein and hyperphosphorylation of tau, which evoke neuronal…

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Prevention of Alzheimer’s Disease Pathology by Cannabinoids: Neuroprotection Mediated by Blockade of Microglial Activation

Alzheimer's disease (AD) is characterized by enhanced β-amyloid peptide (βA) deposition along with glial activation in senile plaques, selective neuronal loss, and cognitive deficits. Cannabinoids are neuroprotective agents against excitotoxicity in…

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Modulation of the Cannabinoid System: A New Perspective for the Treatment of the Alzheimer’s Disease

The pathogenesis of Alzheimer’s disease (AD) is somewhat complex and has yet to be fully understood. As the effectiveness of the therapy currently available for AD has proved to be…

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Cannabinoid receptor 2 deficiency results in reduced neuroinflammation in an Alzheimer’s disease mouse model

Several studies have indicated that the cannabinoid receptor 2 (CB2) plays an important role in neuroinflammation associated with Alzheimer's disease (AD) progression. The present study examined the role of CB2…

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Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users

Introduction: Chronic cannabis use is associated with neuroanatomical alterations in the hippocampus. While adverse impacts of cannabis use are generally attributed to Δ9-tetrahydrocannabinol, emerging naturalistic evidence suggests cannabidiol (CBD) is neuroprotective…

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The United Chemicals of Cannabis: Beneficial Effects of Cannabis Phytochemicals on the Brain and Cognition

‘Medicinal cannabis’ can be defined as pharmaceutical grade cannabis-based products used for the treatment of illness. Beneficial treatment effects of cannabidiol (CBD), a major non-intoxicating compound isolated from the cannabis…

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Cannabidiol Reverses Deficits in Hippocampal LTP in a Model of Alzheimer’s Disease

Here we demonstrate for the first time that cannabidiol (CBD) acts to protect synaptic plasticity in an in vitro model of Alzheimer’s disease (AD). The non-psycho active component of Cannabis sativa,…

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Eating ants, grasshoppers and silkworms could protect against CANCER because ‘they have more antioxidants than orange juice’

Scientists at the University of Rome made drinks out of ground up insectsThey tested them for health-giving antioxidants such as vitamins A, C and ESome types had five times as…

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Teen are LESS likely to use marijuana in states with recreational use laws, study finds

Researchers analyzed youth cannabis use from 1993 to 2017There was no change tied to medical marijuana, but rates dropped 10% with recreational marijuana lawsThe researchers looked at overall changes nationwide,…

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Fried food DOES increase your risk of coronary artery disease: Scientists discover fries block the blood vessels that supply the heart after years of ‘conflicting’ results

Past studies have been mixed on how fried food affects our blood vesselsLatest research shows eating deep-fried 'treats' once a week raises the riskHeating oils causes blood pressure to rise…

Continue ReadingFried food DOES increase your risk of coronary artery disease: Scientists discover fries block the blood vessels that supply the heart after years of ‘conflicting’ results

Cancer breakthrough: Scientists discover a new Achilles’ Heel of tumors that causes them to self-destruct – and we already have a drug that can target it

The technique worked on a range of human forms of the disease and mice with bowel and blood cancerThe team at the University of Pennsylvania report the finding in a…

Continue ReadingCancer breakthrough: Scientists discover a new Achilles’ Heel of tumors that causes them to self-destruct – and we already have a drug that can target it

CBD was easily a fit for me’: Two-time Masters champions Bubba Watson reveals he has been using CANNABIS OIL to prolong his career

Bubba Watson believes using cannabis oil will help prolong his golf careerThe 40-year-old uses cannabinoid (CBD) which purports to have health benefitsCBD is a non-intoxicating chemical found in hemp and…

Continue ReadingCBD was easily a fit for me’: Two-time Masters champions Bubba Watson reveals he has been using CANNABIS OIL to prolong his career