PURPOSE: Orthosteric cannabinoid receptor 1 (CB1) activation leads to decreases in intraocular pressure (IOP). However, use of orthosteric CB1 agonists chronically has several disadvantages, limiting their usefulness as clinically relevant drugs.…
BACKGROUND: Emerging neuroprotective strategies are being explored to preserve the retina from degeneration, that occurs in eye pathologies like glaucoma, diabetic retinopathy, age-related macular degeneration, and retinitis pigmentosa. Incidentally, neuroprotection…
Abstract : Nearly half a century has passed since the demonstration that cannabis and its chief psychoactive component Δ9-THC lowers intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic…
The aim of the present work was the evaluation of a topic application of cannabinoids in 5 patients affected by late stage open angle glaucoma (OAG) in which both surgical…
Thirty-two different cannabinoids were tested for their ability to reduce intraocular pressure (IOP) in the rabbit. These included many of Δ9-and Δ8 -THC derivatives and metabolites along with other natural and…
Objective To discuss the clinical effects, including toxicological data, of marijuana and its many constituent compounds on the eye and the remainder of the body. A perspective is given on the…
The search for new ocular hypotensive agents represents a frontier of current eye research because blindness due to optic neuropathy occurs insidiously in 10% of all patients affected by glaucoma.…
The leading cause of irreversible blindness is glaucoma, a disease normally characterized by the development of ocular hypertension and consequent damage to the optic nerve at its point of retinal…
Medical cannabinoid products are widely used in Canada to treat medical symptoms of all kinds, and gastrointestinal (GI) symptoms are among the most commonly cited reasons for use (1). Cannabis…
Δ9-Tetrahydrocannabinol (the active ingredient of marijuana), as well as endogenous and synthetic cannabinoids, exert many biological functions by activating two types of cannabinoid receptors, CB1 and CB2 receptors. CB1 receptors have been detected…
Cannabis is a complex plant with a complex history. It's been cultivated for at least 6,000 years, but because of its modern legal status, we're still learning new things about its medicinal…
When Shavo Odadjian, bassist of the band System of a Down, told me he was launching a cannabis strain called “Church,” I could not help but find it funny. Weed and religion don’t go…
A yellow vest protester waves a French national flag on International Workers Day in the Montparnasse district of Paris, France, on Wednesday, May 1, 2019. French President Emmanuel Macron has…
The U.S. government is growing the largest crop of research marijuana in five years, responding to interest in varieties with high levels of THC and CBD. The government is the…
It is believed the double trepanation procedure was survived by the warrior as it showed signs of healing May have been inflicted on the man as part of 'brain surgery' to…
LEGO is moving to a totally renewed and ecological production with Hemp by 2030. LEGO has served as the literal building block for generations of children’s toys. Using an oil-based…
INTRODUCTION: Nicotine stimulates fibroblast proliferation while increasing inflammation and fibrosis of tissues. The cannabinoid receptor 1 (CB1R) is mainly located in the CNS, while cannabinoid receptor 2 (CB2R) is located…
Although the mortality rates of cirrhosis are underestimated, its socioeconomic burden has demonstrated a significant global impact. Cirrhosis is defined by the disruption of normal liver architecture after years of…
Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness. Asthma remains a major public health problem and, at present, there are no effective interventions capable of reversing airway remodelling. Cannabidiol (CBD) is known to exert…
Cannabinoids apparently act on inflammation through mechanisms different from those of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs). As a class, the cannabinoids are generally free from the adverse effects…
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